Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition-Reference-Cited by-同舟云学术

Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition

Published:2017-07-14 Issue:6347 Volume:357 Page:212-216
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zenk Fides¹²^ORCID,Loeser Eva¹,Schiavo Rosaria¹,Kilpert Fabian³^ORCID,Bogdanović Ozren⁴⁵⁶^ORCID,Iovino Nicola¹^ORCID

Affiliation:

1. Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany.

2. Faculty of Biology, University of Freiburg, D-79104 Freiburg, Germany.

3. Bioinformatics Facility, Max Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany.

4. Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.

5. St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.

6. ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, Perth, Western Australia 6009, Australia.

Abstract

Intergenerational transcription taming Parents provide genetic information that guides the development of the offspring. Zenk et al. show that epigenetic information, in the form of the repressive mark H3K27me3, is also propagated to the offspring and regulates proper gene expression in the embryo. Preventing the propagation of maternally inherited H3K27me3 led to precocious gene activation and, ultimately, embryo lethality. Science , this issue p. 212

Funder

Max Planck Society

DFG

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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