Geniculocortical Input Drives Genetic Distinctions Between Primary and Higher-Order Visual Areas

Author:

Chou Shen-Ju1,Babot Zoila1,Leingärtner Axel1,Studer Michele2,Nakagawa Yasushi1,O'Leary Dennis D. M.1

Affiliation:

1. Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.

2. Institute of Biology Valrose, INSERM, Nice, France.

Abstract

Dividing the Brain The cerebral cortex of the brain is organized into primary cortical areas, which receive direct inputs from the thalamus, and higher-order cortical areas, which in turn receive inputs from one or more primary cortical areas. Chou et al. (p. 1239 ) investigated the mechanisms underlying the specification of higher-order cortical areas. Input from the dorsal lateral geniculate nucleus into the primary visual area (V1) is required to drive the genetic and functional differentiation of a large visual cortical field into primary and higher-order visual areas. Thalamocortical axon input acts on a large visual cortical field. The afferents from the dorsal lateral geniculate are necessary to further refine the cortex into subareas that distinguish V1 from higher processing areas. In the relatively simple model that emerges from these findings, sensory input is essential to distinguish primary and higher-order cortical areas.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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