Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency-Reference-Cited by-同舟云学术

Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency

Published:2012-09-28 Issue:6102 Volume:337 Page:1684-1688
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bogunovic Dusan¹,Byun Minji¹,Durfee Larissa A.²,Abhyankar Avinash¹,Sanal Ozden³,Mansouri Davood⁴,Salem Sandra⁵,Radovanovic Irena⁵,Grant Audrey V.⁶,Adimi Parisa⁴,Mansouri Nahal¹⁴,Okada Satoshi¹,Bryant Vanessa L.¹,Kong Xiao-Fei¹,Kreins Alexandra¹,Velez Marcela Moncada¹,Boisson Bertrand¹,Khalilzadeh Soheila⁴,Ozcelik Ugur³,Darazam Ilad Alavi⁴,Schoggins John W.⁷,Rice Charles M.⁷,Al-Muhsen Saleh⁸⁹,Behr Marcel¹⁰,Vogt Guillaume¹⁶,Puel Anne⁶,Bustamante Jacinta⁶¹¹,Gros Philippe⁵,Huibregtse Jon M.²,Abel Laurent¹⁶,Boisson-Dupuis Stéphanie¹⁶,Casanova Jean-Laurent¹⁶¹²

Affiliation:

1. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

2. Section of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA.

3. Immunology Division and Pediatric Chest Disease Department, Hacettepe University Children’s Hospital, 06100 Ankara, Turkey.

4. Division of Infectious Diseases and Clinical Immunology, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Teheran, Iran.

5. Department of Biochemistry, McGill University, Montreal, Canada.

6. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, U980, University Paris Descartes, Necker Medical School, 75015 Paris, France.

7. Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.

8. Prince Naif Center for Immunology Research, Department of Pediatrics, College of Medicine, King Saud University, Riyadh, 11211, Saudi Arabia.

9. Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Saudi Arabia.

10. Research Institute, McGill University Health Center, Montreal, Canada.

11. Center for the Study of Primary Immunodeficiencies, Assistance Publique–Hopitaux de Paris, Necker Hospital, Paris, France.

12. Pediatric Hematology-Immunology Unit, Necker Hospital, 75015 Paris, France.

Abstract

Tuberculosis Vaccine Conundrum Some children experience severe clinical disease when they are vaccinated against tuberculosis, an attenuated live vaccine that is normally innocuous in humans. Several germline mutations have been identified that account for this susceptibility, and now Bogunovic et al. (p. 1684 , published online 2 August) add another to the list— ISG15 . Uncovering this mutation, which is inherited in an autosomal recessive manner, was a surprise because studies with mice deficient in ISG15 showed enhanced susceptibility to some viral, but not bacterial, infections. Nevertheless, patients lacking ISG15 were not able to produce adequate amounts of interferon-γ, a cytokine critical for clearance of the bacteria.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

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2. Human genetics of infectious diseases: between proof of principle and paradigm

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