A Conserved p38 MAP Kinase Pathway in Caenorhabditis elegans Innate Immunity-Reference-Cited by-同舟云学术

A Conserved p38 MAP Kinase Pathway in Caenorhabditis elegans Innate Immunity

Published:2002-07-26 Issue:5581 Volume:297 Page:623-626
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kim Dennis H.¹,Feinbaum Rhonda¹,Alloing Geneviève¹,Emerson Fred E.¹,Garsin Danielle A.¹,Inoue Hideki²,Tanaka-Hino Miho²,Hisamoto Naoki²,Matsumoto Kunihiro²,Tan Man-Wah¹,Ausubel Frederick M.¹

Affiliation:

1. Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

2. Department of Molecular Biology, Graduate School of Science, Nagoya University and CREST, Japan Science and Technology Corporation, Chikusa-ku, Nagoya 464-8602, Japan.

Abstract

A genetic screen for Caenorhabditis elegans mutants with enhanced susceptibility to killing by Pseudomonas aeruginosa led to the identification of two genes required for pathogen resistance: sek-1 , which encodes a mitogen-activated protein (MAP) kinase kinase, and nsy-1 , which encodes a MAP kinase kinase kinase. RNA interference assays and biochemical analysis established that a p38 ortholog, pmk-1 , functions as the downstream MAP kinase required for pathogen defense. These data suggest that this MAP kinase signaling cassette represents an ancient feature of innate immune responses in evolutionarily diverse species.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

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