Myc-Induced T Cell Leukemia in Transgenic Zebrafish-Reference-Cited by-同舟云学术

Myc-Induced T Cell Leukemia in Transgenic Zebrafish

Published:2003-02-07 Issue:5608 Volume:299 Page:887-890
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Langenau David M.¹,Traver David²,Ferrando Adolfo A.¹,Kutok Jeffery L.³,Aster Jon C.³,Kanki John P.¹,Lin Shuo⁴,Prochownik Ed⁵,Trede Nikolaus S.²,Zon Leonard I.²,Look A. Thomas¹

Affiliation:

1. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

2. Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

4. Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.

5. Division of Hematology/Oncology, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213, USA.

Abstract

The zebrafish is an attractive model organism for studying cancer development because of its genetic accessibility. Here we describe the induction of clonally derived T cell acute lymphoblastic leukemia in transgenic zebrafish expressing mouse c- myc under control of the zebrafish Rag2 promoter. Visualization of leukemic cells expressing a chimeric transgene encoding Myc fused to green fluorescent protein (GFP) revealed that leukemias arose in the thymus, spread locally into gill arches and retro-orbital soft tissue, and then disseminated into skeletal muscle and abdominal organs. Leukemic cells homed back to the thymus in irradiated fish transplanted with GFP-labeled leukemic lymphoblasts. This transgenic model provides a platform for drug screens and for genetic screens aimed at identifying mutations that suppress or enhance c- myc – induced carcinogenesis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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