Ancient Pathways Programmed by Small RNAs-Reference-Cited by-同舟云学术

Ancient Pathways Programmed by Small RNAs

Published:2002-05-17 Issue:5571 Volume:296 Page:1265-1269
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zamore Phillip D.¹

Affiliation:

1. Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Lazare Research Building, Room 825, 364 Plantation Street, Worcester, MA 01605, USA.

Abstract

Double-stranded RNA can now be used in a wide variety of eukaryotes to suppress the expression of virtually any gene, allowing the rapid analysis of that gene's function, a technique known as RNA interference. But how cells use the information in double-stranded RNA to suppress gene expression and why they contain the machinery to do so remain the subjects of intense scrutiny. Current evidence suggests that RNA interference and other “RNA silencing” phenomena reflect an elaborate cellular apparatus that eliminates abundant but defective messenger RNAs and defends against molecular parasites such as transposons and viruses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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