Regulation of Sexual Development of Plasmodium by Translational Repression-Reference-Cited by-同舟云学术

Regulation of Sexual Development of Plasmodium by Translational Repression

Published:2006-08-04 Issue:5787 Volume:313 Page:667-669
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mair Gunnar R.¹²³⁴,Braks Joanna A. M.¹²³⁴,Garver Lindsey S.¹²³⁴,Wiegant Joop C. A. G.¹²³⁴,Hall Neil¹²³⁴,Dirks Roeland W.¹²³⁴,Khan Shahid M.¹²³⁴,Dimopoulos George¹²³⁴,Janse Chris J.¹²³⁴,Waters Andrew P.¹²³⁴

Affiliation:

1. Department of Parasitology, Leiden University Medical Centre, 2333 ZA Leiden, Netherlands.

2. Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.

3. Department of Molecular Cell Biology, Leiden University Medical Centre, 2333 ZA Leiden, Netherlands.

4. The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.

Abstract

Translational repression of messenger RNAs (mRNAs) plays an important role in sexual differentiation and gametogenesis in multicellular eukaryotes. Translational repression and mRNA turnover were shown to influence stage-specific gene expression in the protozoan Plasmodium . The DDX6-class RNA helicase, DOZI (development of zygote inhibited), is found in a complex with mRNA species in cytoplasmic bodies of female, blood-stage gametocytes. These translationally repressed complexes are normally stored for translation after fertilization. Genetic disruption of pbdozi inhibits the formation of the ribonucleoprotein complexes, and instead, at least 370 transcripts are diverted to a degradation pathway.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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