Vesicular Glutamate Transporters 1 and 2 Target to Functionally Distinct Synaptic Release Sites-Reference-Cited by-同舟云学术

Vesicular Glutamate Transporters 1 and 2 Target to Functionally Distinct Synaptic Release Sites

Published:2004-06-18 Issue:5678 Volume:304 Page:1815-1819
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fremeau Robert T.¹²³⁴⁵,Kam Kaiwen¹²³⁴⁵,Qureshi Tayyaba¹²³⁴⁵,Johnson Juliette¹²³⁴⁵,Copenhagen David R.¹²³⁴⁵,Storm-Mathisen Jon¹²³⁴⁵,Chaudhry Farrukh A.¹²³⁴⁵,Nicoll Roger A.¹²³⁴⁵,Edwards Robert H.¹²³⁴⁵

Affiliation:

1. Department of Neurology, Graduate Programs in Neuroscience and Cell Biology, University of California San Francisco School of Medicine, CA 94143, USA.

2. Department of Physiology, Graduate Programs in Neuroscience and Cell Biology, University of California San Francisco School of Medicine, CA 94143, USA.

3. Department of Cellular and Molecular Pharmacology, Graduate Programs in Neuroscience and Cell Biology, University of California San Francisco School of Medicine, CA 94143, USA.

4. Department of Ophthalmology, Graduate Programs in Neuroscience and Cell Biology, University of California San Francisco School of Medicine, CA 94143, USA.

5. Anatomical Institute and Centre for Molecular Biology and Neuroscience, University of Oslo, Post Office Box 1105 Blindern, N-0317 Oslo, Norway.

Abstract

Vesicular glutamate transporters (VGLUTs) 1 and 2 show a mutually exclusive distribution in the adult brain that suggests specialization for synapses with different properties of release. Consistent with this distribution, inactivation of the VGLUT1 gene silenced a subset ofexcitatory neurons in the adult. However, the same cell populations exhibited VGLUT1-independent transmission early in life. Developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity. The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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