Quantitative Trait Loci for Refractoriness of Anopheles gambiae to Plasmodium cynomolgi B-Reference-Cited by-同舟云学术

Quantitative Trait Loci for Refractoriness of Anopheles gambiae to Plasmodium cynomolgi B

Published:1997-04-18 Issue:5311 Volume:276 Page:425-428
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zheng Liangbiao¹²,Cornel Anton J.¹²,Wang Rui¹²,Erfle Holger¹²,Voss Hartmut¹²,Ansorge Wilhelm¹²,Kafatos Fotis C.¹²,Collins Frank H.¹²

Affiliation:

1. L. Zheng, R. Wang, H. Erfle, H. Voss, W. Ansorge, F. C. Kafatos, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

2. A. J. Cornel and F. H. Collins, Centers for Disease Control and Prevention, 4770 Buford Highway, Mail Stop F22, Chamblee, GA 30341, USA.

Abstract

The severity of the malaria pandemic in the tropics is aggravated by the ongoing spread of parasite resistance to antimalarial drugs and mosquito resistance to insecticides. A strain of Anopheles gambiae , normally a major vector for human malaria in Africa, can encapsulate and kill the malaria parasites within a melanin-rich capsule in the mosquito midgut. Genetic mapping revealed one major and two minor quantitative trait loci (QTLs) for this encapsulation reaction. Understanding such antiparasite mechanisms in mosquitoes may lead to new strategies for malaria control.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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5. The new refractory strain (L35) was derived from the previous one (1) and is homozygous for collarless (7). The new susceptible strain (4Ar/r) is homozygous for pink-eye and red-eye [

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