Affiliation:
1. Center for the Study of Nervous System Injury and Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Abstract
Neuronal death induced by activating
N
-methyl-
d
-aspartate (NMDA) receptors has been linked to Ca
2+
and Na
+
influx through associated channels. Whole-cell recording from cultured mouse cortical neurons revealed a NMDA-evoked outward current,
I
NMDA-K
, carried by K
+
efflux at membrane potentials positive to –86 millivolts. Cortical neurons exposed to NMDA in medium containing reduced Na
+
and Ca
2+
(as found in ischemic brain tissue) lost substantial intracellular K
+
and underwent apoptosis. Both K
+
loss and apoptosis were attenuated by increasing extracellular K
+
, even when voltage-gated Ca
2+
channels were blocked. Thus NMDA receptor–mediated K
+
efflux may contribute to neuronal apoptosis after brain ischemia.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
210 articles.
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