A DNA methylation reader complex that enhances gene transcription-Reference-Cited by-同舟云学术

A DNA methylation reader complex that enhances gene transcription

Published:2018-12-07 Issue:6419 Volume:362 Page:1182-1186
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Harris C. Jake¹^ORCID,Scheibe Marion²^ORCID,Wongpalee Somsakul Pop¹^ORCID,Liu Wanlu¹,Cornett Evan M.³^ORCID,Vaughan Robert M.³^ORCID,Li Xueqin⁴^ORCID,Chen Wei⁴,Xue Yan¹^ORCID,Zhong Zhenhui¹⁵^ORCID,Yen Linda¹,Barshop William D.⁶,Rayatpisheh Shima⁶,Gallego-Bartolome Javier¹,Groth Martin¹,Wang Zonghua⁵⁷,Wohlschlegel James A.⁶^ORCID,Du Jiamu⁴^ORCID,Rothbart Scott B.³^ORCID,Butter Falk²^ORCID,Jacobsen Steven E.¹⁸^ORCID

Affiliation:

1. Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA 90095, USA.

2. Quantitative Proteomics, Institute of Molecular Biology, 55128 Mainz, Germany.

3. Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

4. National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China.

5. State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, 350002 Fuzhou, China.

6. Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

7. Institute of Oceanography, Minjiang University, 350108 Fuzhou, China.

8. Howard Hughes Medical Institute, University of California at Los Angeles, Los Angeles, CA, USA.

Abstract

DNA methylation promotes transcription DNA methylation generally represses transcription, but in some instances, it has also been implicated in transcription activation. Harris et al. identified a protein complex in Arabidopsis that is recruited to chromatin by DNA methylation. This complex specifically activated the transcription of genes that are already mildly transcribed but had no effect on transcriptionally silent genes such as transposable elements. The complex thereby counteracts the repression effect caused by transposon insertion in neighboring genes while leaving transposons silent. Thus, by balancing both repressive and activating transcriptional effects, DNA methylation can act to fine-tune gene expression. Science , this issue p. 1182

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

1. DNA methylation pathways and their crosstalk with histone methylation

2. Conservation and divergence of methylation patterning in plants and animals

3. Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation

4. RNA-directed DNA methylation: an epigenetic pathway of increasing complexity

5. The industrial melanism mutation in British peppered moths is a transposable element

Cited by 188 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. FTO promotes gefitinib-resistance by enhancing PELI3 expression and autophagy in non-small cell lung cancer;Pulmonary Pharmacology & Therapeutics;2024-12

2. The SET‐Domain‐Containing Protein MdSDG26 Negatively Regulates Alternaria alternata Resistance in Apple;Plant, Cell & Environment;2024-09-11

3. lncRNAs and epigenetics regulate plant's resilience against biotic stresses;Plant Physiology and Biochemistry;2024-09

4. Epigenetic gene regulation in plants and its potential applications in crop improvement;Nature Reviews Molecular Cell Biology;2024-08-27

5. The Role of Epigenetic Mechanisms in the Pathogenesis of Hepatitis C Infection;Biomolecules;2024-08-10