bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS-Reference-Cited by-同舟云学术

bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS

Published:2004-12-17 Issue:5704 Volume:306 Page:2111-2115
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Arnett Heather A.¹²³⁴,Fancy Stephen P. J.¹²³⁴,Alberta John A.¹²³⁴,Zhao Chao¹²³⁴,Plant Sheila R.¹²³⁴,Kaing Sovann¹²³⁴,Raine Cedric S.¹²³⁴,Rowitch David H.¹²³⁴,Franklin Robin J. M.¹²³⁴,Stiles Charles D.¹²³⁴

Affiliation:

1. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

2. Cambridge Centre for Brain Repair and Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.

3. Lineberger Comprehensive Cancer Institute, University of North Carolina, Chapel Hill, NC 27599, USA.

4. Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Abstract

Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that are expressed in myelinating oligodendrocytes and their progenitor cells in the developing central nervous system (CNS). Olig2 is necessary for the specification of oligodendrocytes, but the biological functions of Olig1 during oligodendrocyte lineage development are poorly understood. We show here that Olig1 function in mice is required not to develop the brain but to repair it. Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

1. R. H. Miller, Prog. Neurobiol.67, 451 (2002).

2. S. E. Pfeiffer, A. E. Warrington, R. Bansal, Trends Cell Biol.3, 191 (1993).

3. W. D. Richardson, N. P. Pringle, W. P. Yu, A. C. Hall, Dev. Neurosci.19, 58 (1997).

4. C. S. Raine, J. Neuroimmunol.77, 135 (1997).

5. Diverse Targets for Intervention during Inflammatory and Neurodegenerative Phases of Multiple Sclerosis

Cited by 365 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Disruption of myelin structure and oligodendrocyte maturation in a macaque model of congenital Zika infection;Nature Communications;2024-06-18

2. Dysregulated Cholinergic Signaling Inhibits Oligodendrocyte Maturation Following Demyelination;The Journal of Neuroscience;2024-05-15

3. Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration;Cell;2024-05

4. Remyelination in the Central Nervous System;Cold Spring Harbor Perspectives in Biology;2024-02-05

5. Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination;Developmental Cell;2023-11