Envelope-Constrained Neutralization-Sensitive HIV-1 After Heterosexual Transmission-Reference-Cited by-同舟云学术

Envelope-Constrained Neutralization-Sensitive HIV-1 After Heterosexual Transmission

Published:2004-03-26 Issue:5666 Volume:303 Page:2019-2022
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Derdeyn Cynthia A.¹²³⁴⁵,Decker Julie M.¹²³⁴⁵,Bibollet-Ruche Frederic¹²³⁴⁵,Mokili John L.¹²³⁴⁵,Muldoon Mark¹²³⁴⁵,Denham Scott A.¹²³⁴⁵,Heil Marintha L.¹²³⁴⁵,Kasolo Francis¹²³⁴⁵,Musonda Rosemary¹²³⁴⁵,Hahn Beatrice H.¹²³⁴⁵,Shaw George M.¹²³⁴⁵,Korber Bette T.¹²³⁴⁵,Allen Susan¹²³⁴⁵,Hunter Eric¹²³⁴⁵

Affiliation:

1. Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 USA.

2. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 USA.

3. Howard Hughes Medical Institute, University of Alabama at Birmingham, Birmingham, AL 35294 USA.

4. HIV Sequence Database, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.

5. Department of Mathematics, University of Manchester Institute of Science and Technology, Manchester, UK.

Abstract

Heterosexual transmission accounts for the majority of human immunodeficiency virus–1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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