Dependence of Germinal Center B Cells on Expression of CD21/CD35 for Survival-Reference-Cited by-同舟云学术

Dependence of Germinal Center B Cells on Expression of CD21/CD35 for Survival

Published:1998-04-24 Issue:5363 Volume:280 Page:582-585
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fischer Michael B.¹²³,Goerg Siegfried¹²³,Shen LiMing¹²³,Prodeus Andrey P.¹²³,Goodnow Christopher C.¹²³,Kelsoe Garnett¹²³,Carroll Michael C.¹²³

Affiliation:

1. M. B. Fischer, S. Goerg, L. Shen, A. P. Prodeus, M. C. Carroll, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

2. C. C. Goodnow, Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.

3. G. Kelsoe, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201–1509, USA.

Abstract

Affinity-driven selection of B lymphocytes within germinal centers is critical for the development of high-affinity memory cells and host protection. To investigate the role of the CD21/CD35 coreceptor in B cell competition for follicular retention and survival within the germinal center, either Cr2 + or Cr2 null lysozyme-specific transgenic B cells were adoptively transferred into normal mice immunized with duck (DEL) or turkey (TEL) lysozyme, which bind with different affinities. In mice injected with high-affinity turkey lysozyme, Cr2 null B cells responded by follicular retention; however, they could not survive within germinal centers. This suggests that CD21 provides a signal independent of antigen that is required for survival of B cells in the germinal center.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. J. J. Weis, T. F. Tedder, D. T. Fearon, Proc. Natl. Acad Sci. U.S.A. 81, 881 (1984); Molina H., Kinoshita T., Inoue K., Carel J. C., Holers V. M., J. Immunol. 145, 2974 (1990).

2. Ahearn J. M., et al., Immunity4, 251 (1996).

3. Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.

4. Croix D. A., et al., J. Exp. Med.183, 1857 (1996).

5. Fearon D. T., Wong W. W., Annu. Rev. Immunol.1, 243 (1983).

Cited by 242 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Unmasking the NLRP3 inflammasome in dendritic cells as a potential therapeutic target for autoimmunity, cancer, and infectious conditions;Life Sciences;2024-07

2. B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles;Communications Biology;2024-05-16

3. Molecular mechanism of complement inhibition by the trypanosome receptor ISG65;eLife;2024-04-24

4. Molecular mechanism of complement inhibition by the trypanosome receptor ISG65;2024-04-05

5. Unveiling spatial complexity in solid tumor immune microenvironments through multiplexed imaging;Frontiers in Immunology;2024-03-19