Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures-Reference-Cited by-同舟云学术

Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures

Published:2010-05-21 Issue:5981 Volume:328 Page:1009-1014
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Percec Virgil¹,Wilson Daniela A.¹,Leowanawat Pawaret¹,Wilson Christopher J.¹,Hughes Andrew D.¹,Kaucher Mark S.¹,Hammer Daniel A.²³,Levine Dalia H.³,Kim Anthony J.³,Bates Frank S.⁴,Davis Kevin P.⁴,Lodge Timothy P.⁴⁵,Klein Michael L.⁶,DeVane Russell H.⁶,Aqad Emad¹,Rosen Brad M.¹,Argintaru Andreea O.¹,Sienkowska Monika J.¹,Rissanen Kari⁷,Nummelin Sami⁷⁸,Ropponen Jarmo⁷

Affiliation:

1. Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104–6323, USA.

2. Department of Bioengineering and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104–6323, USA.

4. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.

5. Department of Chemistry, University of Minnesota, Minneapolis, MN 55455–0431, USA.

6. Institute for Computational Molecular Science, Temple University, Philadelphia, PA 19122, USA.

7. Nanoscience Center, Department of Chemistry, University of Jyväskylä, 40014 JYU, Finland.

8. Molecular Materials, Department of Applied Physics, School of Science and Technology, Aalto University, FI-02150, Espoo, Finland.

Abstract

Janus Drug Delivery Vehicle Efficient drug delivery vehicles need to be produced in a limited size range and with uniform size distribution. The self-assembly of traditional small-molecule and polymeric amphiphiles has led to the production of micelles, liposomes, polymeric micelles, and polymersomes for use in drug delivery applications. Now, Percec et al. (p. 1009 ) describe the self-assembly of Janus-type (i.e., two-headed) dendrimers to produce monodisperse supramolecular constructs, termed “dendrimersomes,” and other complex architectures. The structures, which showed long-term stability as well as very narrow size distributions, were easily produced by the injection of an ethanolic solution of the dendrimer into water. The dendrimersomes could be loaded with the anticancer drug doxorubicin and exhibited controlled drug release with changing pH.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. The Fluid Mosaic Model of the Structure of Cell Membranes

2. Diffusion of univalent ions across the lamellae of swollen phospholipids

3. Replicating vesicles as models of primitive cell growth and division

4. Artificial transmembrane ion channels from self-assembling peptide nanotubes

5. Self-assembly of amphiphilic dendritic dipeptides into helical pores

Cited by 658 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis of biodegradable Janus dendrimer conjugates with chlorambucil and naproxen;Tetrahedron;2024-10

2. Amphiphilic Janus dendrimer for targeted-drug delivery to human cancer cells;Tetrahedron;2024-09

3. Two-dimensional crystallization of precise side-chain giant molecules with constant building blocks ratio;Giant;2024-08

4. Steps Toward Recapitulating Endothelium: A Perspective on the Next Generation of Hemocompatible Coatings;Macromolecular Bioscience;2024-07-29

5. Targeted delivery of TGF-β mRNA to lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers.;2024-07-12