Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination-Reference-Cited by-同舟云学术

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

Published:2011-10-21 Issue:6054 Volume:334 Page:376-380
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Dueber Erin C.¹,Schoeffler Allyn J.¹,Lingel Andreas¹,Elliott J. Michael²,Fedorova Anna V.¹,Giannetti Anthony M.³,Zobel Kerry¹,Maurer Brigitte⁴,Varfolomeev Eugene¹,Wu Ping⁴,Wallweber Heidi J. A.⁴,Hymowitz Sarah G.⁴,Deshayes Kurt¹,Vucic Domagoj¹,Fairbrother Wayne J.¹

Affiliation:

1. Department of Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

2. Department of Protein Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

3. Department of Biochemical Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

4. Department of Structural Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

Abstract

Antagonist binding to an apoptosis inhibitor releases inhibition by promoting dimerization required for autoubiquitination.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference37 articles.

1. IAP proteins: blocking the road to death's door

2. The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer

3. Caspase activation – stepping on the gas or releasing the brakes? Lessons from humans and flies

4. Antagonists of IAP proteins as cancer therapeutics

5. The inhibitors of apoptosis (IAPs) as cancer targets

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