Autophagy Defends Cells Against Invading Group A Streptococcus-Reference-Cited by-同舟云学术

Autophagy Defends Cells Against Invading Group A Streptococcus

Published:2004-11-05 Issue:5698 Volume:306 Page:1037-1040
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Nakagawa Ichiro¹²³⁴⁵,Amano Atsuo¹²³⁴⁵,Mizushima Noboru¹²³⁴⁵,Yamamoto Akitsugu¹²³⁴⁵,Yamaguchi Hitomi¹²³⁴⁵,Kamimoto Takahiro¹²³⁴⁵,Nara Atsuki¹²³⁴⁵,Funao Junko¹²³⁴⁵,Nakata Masanobu¹²³⁴⁵,Tsuda Kayoko¹²³⁴⁵,Hamada Shigeyuki¹²³⁴⁵,Yoshimori Tamotsu¹²³⁴⁵

Affiliation:

1. Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, Japan.

2. Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, Japan.

3. PRESTO, Japan Science and Technology Agency, Kawaguchi-Saitama 332-0012, Japan.

4. CREST, Japan Science and Technology Agency, Kawaguchi-Saitama 332-0012, Japan.

5. Department of Bioregulation and Metabolism, The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan.

Abstract

We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5 –/– cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference22 articles.

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