Polysialylation controls dendritic cell trafficking by regulating chemokine recognition-Reference-Cited by-同舟云学术

Polysialylation controls dendritic cell trafficking by regulating chemokine recognition

Published:2016-01-08 Issue:6269 Volume:351 Page:186-190
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kiermaier Eva¹,Moussion Christine¹,Veldkamp Christopher T.²³,Gerardy-Schahn Rita⁴,de Vries Ingrid¹,Williams Larry G.²,Chaffee Gary R.²,Phillips Andrew J.²,Freiberger Friedrich⁴,Imre Richard⁵,Taleski Deni⁶,Payne Richard J.⁶,Braun Asolina⁷,Förster Reinhold⁷,Mechtler Karl⁵,Mühlenhoff Martina⁴,Volkman Brian F.³,Sixt Michael¹

Affiliation:

1. Institute of Science and Technology Austria (IST Austria), Am Campus 1, 3400 Klosterneuburg, Austria.

2. Department of Chemistry, University of Wisconsin–Whitewater, 800 West Main Street, Whitewater, WI 53190, USA.

3. Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

4. Institute for Cellular Chemistry, Hannover Medical School [Medizinische Hochschule Hannover (MHH)], Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

5. Research Institute of Molecular Pathology, Vienna Biocenter, Dr. Bohr Gasse 7, 1030 Vienna, Austria.

6. School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.

7. Institute of Immunology, Hannover Medical School (MHH), Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

Abstract

A chemokine's sugary release As immune cells survey the body for pathogens, they circulate through the blood and migrate through the lymphatic system. The latter route allows for tissues and lymph nodes—the central hubs of the immune system—to communicate. Kiermaier et al. reveal the importance of the monosaccharide sialic acid in keeping immune cells in motion. Multiple sialic acids decorate the surface CCR7 on immune cells. CCR7 recognizes proteins called chemokines, which direct where cells move in the body. Sialic acids on CCR7 release one such chemokine present on lymph node endothelial cells from an inhibited state, allowing immune cells to enter lymph nodes. Science , this issue p. 186

Funder

European Research Council

STROMA (Stromal Cell–Immune Cell Interactions in Health and Disease)

Austrian Science Foundation (FWF)

FWF

U.S. NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. Polysialic acid in the plasticity of the developing and adult vertebrate nervous system