Affiliation:
1. Department of Anatomy, University of California, San Francisco, CA 94143-2822, USA.
Abstract
Toward Addiction
Addiction can result when substances, such as drugs or alcohol, co-opt the brain's natural reward system.
Shohat-Ophir
et al.
(p.
1351
; see the Perspective by
Zars
) explored this potential in
Drosophila
by examining the relationship between the natural reward stimulated by mating and the unnatural reward offered by ethanol consumption. Males deprived of mating increased consumption of ethanol, and, when permitted to mate following deprivation, their ethanol consumption decreased. At a mechanistic level, mating increased the neurotransmitter neuropeptide F (NPF), while mate deprivation decreased NPF levels.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
163 articles.
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