Cytokinin Signaling and Its Inhibitor AHP6 Regulate Cell Fate During Vascular Development

Author:

Mähönen Ari Pekka12345,Bishopp Anthony12345,Higuchi Masayuki12345,Nieminen Kaisa M.12345,Kinoshita Kaori12345,Törmäkangas Kirsi12345,Ikeda Yoshihisa12345,Oka Atsuhiro12345,Kakimoto Tatsuo12345,Helariutta Ykä12345

Affiliation:

1. Plant Molecular Biology Laboratory, Institute of Biotechnology, POB 56, FI-00014, University of Helsinki, Finland.

2. Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.

3. Laboratory of Plant Molecular Biology, Rockefeller University, New York, NY 10021, USA.

4. Laboratory of Molecular Biology, Institute for Chemical Research, Kyoto University, Uji 611-0011, Japan.

5. Department of Biology, FI-20014, University of Turku, Finland.

Abstract

The cell lineages that form the transporting tissues (xylem and phloem) and the intervening pluripotent procambial tissue originate from stem cells near the root tip. We demonstrate that in Arabidopsis, cytokinin phytohormones negatively regulate protoxylem specification. AHP6, an inhibitory pseudophosphotransfer protein, counteracts cytokinin signaling, allowing protoxylem formation. Conversely, cytokinin signaling negatively regulates the spatial domain of AHP6 expression. Thus, by controlling the identity of cell lineages, the reciprocal interaction of cytokinin signaling and its spatially specific modulator regulates proliferation and differentiation of cell lineages during vascular development, demonstrating a previously unrecognized regulatory circuit underlying meristem organization.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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