Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme-Reference-Cited by-全球学者库

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

Published:1997-01-10 Issue:5297 Volume:275 Page:206-209
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gu Yong¹,Kuida Keisuke²,Tsutsui Hiroko³,Ku George¹,Hsiao Kathy¹,Fleming Mark A.¹,Hayashi Nobuki³,Higashino Kazuya³,Okamura Haruki³,Nakanishi Kenji³,Kurimoto Masashi⁴,Tanimoto Tadao⁴,Flavell Richard A.⁵,Sato Vicki¹,Harding Matthew W.¹,Livingston David J.¹,Su Michael S.-S.¹

Affiliation:

1. Y. Gu, G. Ku, K. Hsiao, M. A. Fleming, V. Sato, M. W. Harding, D. J. Livingston, M. S.-S. Su, Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, MA 02139, USA.

2. K. Kuida, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

3. H. Tsutsui, N. Hayashi, K. Higashino, H. Okamura, K. Nakanishi, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Japan.

4. M. Kurimoto and T. Tanimoto, Fujisaki Institute, Hayashibara Biochemical Laboratories, Hayashibara Company Inc., Okayama, Japan.

5. R. A. Flavell, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract

The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-γ inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activated ICE-deficient (ICE −/− ) Kupffer cells synthesized the IGIF precursor but failed to process it into the active form. Interferon-γ and IGIF were diminished in the sera of ICE −/− mice exposed to Propionibacterium acnes and lipopolysaccharide. The lack of multiple proinflammatory cytokines in ICE −/− mice may account for their protection from septic shock.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. Human ICE/CED-3 Protease Nomenclature

2. Molecular Cloning of the Interleukin-1β Converting Enzyme

3. A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

4. Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

5. Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

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