Regulation of Cell Cycle Synchronization by decapentaplegic During Drosophila Eye Development

Author:

Penton Andrea1,Selleck Scott B.2,Hoffmann F. Michael1

Affiliation:

1. A. Penton and F. M. Hoffmann, McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, Madison, WI 53706, USA.

2. S. B. Selleck, Arizona Research Laboratories Division of Neurobiology and Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.

Abstract

In the developing Drosophila eye, differentiation is coordinated with synchronized progression through the cell cycle. Signaling mediated by the transforming growth factor-β-related gene decapentaplegic ( dpp ) was required for the synchronization of the cell cycle but not for cell fate specification. DPP may affect cell cycle synchronization by promoting cell cycle progression through the G 2 -M phases. This synchronization is critical for the precise assembly of the eye.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

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4. Bate M.and Martinez Arias A. Eds. (Cold Spring Harbor Laboratory Press Cold Spring Harbor NY 1993) vol. II pp. 1277–1325.

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