An Exon Splice Enhancer Primes IGF2:IGF2R Binding Site Structure and Function Evolution

Author:

Williams Christopher1,Hoppe Hans-Jürgen2,Rezgui Dellel2,Strickland Madeleine1,Forbes Briony E.3,Grutzner Frank3,Frago Susana2,Ellis Rosamund Z.1,Wattana-Amorn Pakorn1,Prince Stuart N.2,Zaccheo Oliver J.2,Nolan Catherine M.4,Mungall Andrew J.5,Jones E. Yvonne6,Crump Matthew P.1,Hassan A. Bassim2

Affiliation:

1. Department of Organic and Biological Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.

2. Cancer Research UK Tumour Growth Control Group, Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

3. School of Molecular and Biomedical Science, University of Adelaide, Adelaide 5005, Australia.

4. School of Biology and Environmental Science, University College Dublin, Belfield, Dublin, Ireland.

5. Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada.

6. Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

Abstract

Parental genetic conflict may have exploited changes in the coding of a protein loop in a growth factor receptor.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3