Structure and dynamics of the yeast SWR1-nucleosome complex-Reference-Cited by-同舟云学术

Structure and dynamics of the yeast SWR1-nucleosome complex

Published:2018-10-12 Issue:6411 Volume:362 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Willhoft Oliver¹,Ghoneim Mohamed²³^ORCID,Lin Chia-Liang¹^ORCID,Chua Eugene Y. D.¹^ORCID,Wilkinson Martin¹^ORCID,Chaban Yuriy¹,Ayala Rafael¹,McCormack Elizabeth A.¹,Ocloo Lorraine¹,Rueda David S.²³^ORCID,Wigley Dale B.¹

Affiliation:

1. Section of Structural Biology, Department of Medicine, Imperial College London, London SW7 2AZ, UK.

2. Single Molecule Imaging Group, MRC London Institute of Medical Sciences, London W12 0NN, UK.

3. Molecular Virology, Department of Medicine, Imperial College London, London W12 0NN, UK.

Abstract

From DNA unwrapping to histone exchange The yeast SWR1 complex, a member of the INO80 family of nucleosome remodelers, exchanges the H2A-H2B histone dimer for the Htz1 variant–containing dimer. Unlike all other remodelers, SWR1 does not translocate the nucleosome. Willhoft et al. applied structural and single-molecule analyses to show that the interaction between SWR1 and the nucleosome destabilizes the DNA wrapped around the histone core. This SWR1-catalyzed partial unwrapping of the DNA was regulated by adenosine triphosphate (ATP) binding but did not require ATP hydrolysis. Science , this issue p. eaat7716

Funder

Wellcome Trust

Medical Research Council

Cancer Research UK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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