Affiliation:
1. The author is in the Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA.
Abstract
Three reports [Korinek
et al.
(
p. 1784
), Morin
et al
. (
p. 1787
), and Rubinfeld
et al
. (
p. 1790
)] in this issue provide new evidence about the molecular pathway that goes awry in colon cancer and melanoma. The protein β-catenin, previously known to be associated with the colon-cancer-causing adenomatous polyposis coli protein, is shown to be an oncogene in its own right. In his Perspective, Peifer discusses the normal functions of these proteins in mammals and flies and how their dysfunction can lead to cancer.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
281 articles.
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