IRE1α–XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain-Reference-Cited by-同舟云学术

IRE1α–XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain

Published:2019-07-19 Issue:6450 Volume:365 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chopra Sahil¹²³^ORCID,Giovanelli Paolo¹²³,Alvarado-Vazquez Perla Abigail⁴^ORCID,Alonso Sara⁵,Song Minkyung²³,Sandoval Tito A.²³^ORCID,Chae Chang-Suk²³^ORCID,Tan Chen²³^ORCID,Fonseca Miriam M.⁴^ORCID,Gutierrez Silvia⁴,Jimenez Leandro⁶⁷^ORCID,Subbaramaiah Kotha⁸,Iwawaki Takao⁹,Kingsley Philip J.¹⁰^ORCID,Marnett Lawrence J.¹⁰¹¹^ORCID,Kossenkov Andrew V.¹²^ORCID,Crespo Mariano Sanchez⁵^ORCID,Dannenberg Andrew J.⁸,Glimcher Laurie H.¹³¹⁴^ORCID,Romero-Sandoval E. Alfonso⁴^ORCID,Cubillos-Ruiz Juan R.¹²³^ORCID

Affiliation:

1. Weill Cornell Graduate School of Medical Sciences, Cornell University. New York, NY 10065, USA.

2. Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.

3. Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.

4. Department of Anesthesiology, Pain Mechanisms Laboratory, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

5. Instituto de Biología y Genética Molecular, CSIC-Universidad de Valladolid, Valladolid, Spain.

6. Instituto Ludwig de Pesquisa Sobre o Câncer, São Paulo, Brazil.

7. Hospital Sírio-Libanês, São Paulo, Brazil.

8. Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.

9. Division of Cell Medicine, Medical Research Institute, Kazanawa Medical University, Ishikawa, Japan.

10. Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

11. A. B. Hancock Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, USA.

12. Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, PA 19104, USA.

13. Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA.

14. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

Abstract

A “sUPR” target for pain management? The unfolded protein response (UPR) is initiated when unfolded or misfolded proteins accumulate in the endoplasmic reticulum. One highly conserved arm of the UPR, the IRE1α–XBP1 signaling pathway, also plays a role in various other UPR-independent processes, including hypoxia, angiogenesis, and inflammation. Chopra et al. report that this pathway additionally regulates the production of two molecules, cyclooxygenase 2 and microsomal prostaglandin E synthase 1, that help mediate inflammation-induced pain (see the Perspective by Avril and Chevet). When elements of the IRE1α–XBP1 signaling pathway were knocked out, pain behaviors were reduced in two different mouse models of pain. Targeting this pathway may result in improved pain management therapies. Science , this issue p. eaau6499 ; see also p. 224

Funder

National Institutes of Health

U.S. Department of Defense

Plan Nacional de Salud y Farmacia

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference67 articles.

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2. XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

3. XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response