Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention-Reference-Cited by-同舟云学术

Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention

Published:2020-07-03 Issue:6499 Volume:369 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lennon Anne Marie¹²³^ORCID,Buchanan Adam H.⁴^ORCID,Kinde Isaac⁵,Warren Andrew⁵⁶^ORCID,Honushefsky Ashley⁴^ORCID,Cohain Ariella T.⁵^ORCID,Ledbetter David H.⁴^ORCID,Sanfilippo Fred⁷^ORCID,Sheridan Kathleen⁴,Rosica Dillenia⁴^ORCID,Adonizio Christian S.⁴⁸,Hwang Hee Jung⁵^ORCID,Lahouel Kamel¹⁹,Cohen Joshua D.¹²¹⁰¹¹¹²^ORCID,Douville Christopher¹¹¹^ORCID,Patel Aalpen A.⁴^ORCID,Hagmann Leonardo N.⁵,Rolston David D.⁴^ORCID,Malani Nirav⁵^ORCID,Zhou Shibin¹¹¹^ORCID,Bettegowda Chetan¹¹¹¹³,Diehl David L.⁴,Urban Bobbi⁵^ORCID,Still Christopher D.⁴^ORCID,Kann Lisa⁵^ORCID,Woods Julie I.⁴,Salvati Zachary M.⁴,Vadakara Joseph⁴^ORCID,Leeming Rosemary⁴^ORCID,Bhattacharya Prianka⁴,Walter Carroll⁴^ORCID,Parker Alex⁵^ORCID,Lengauer Christoph⁵⁶,Klein Alison¹²¹⁴^ORCID,Tomasetti Cristian¹⁹¹⁵^ORCID,Fishman Elliot K.¹²¹⁶^ORCID,Hruban Ralph H.¹²¹⁷^ORCID,Kinzler Kenneth W.¹²¹¹^ORCID,Vogelstein Bert¹²¹⁰¹¹^ORCID,Papadopoulos Nickolas¹²¹¹¹⁷^ORCID

Affiliation:

1. Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.

2. The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.

3. Department of Medicine Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.

4. Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.

5. Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.

6. Third Rock Ventures, LLC, 29 Newbury Street Boston, MA 02116, USA.

7. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 100 Woodruff Circle Atlanta, GA 30322, USA.

8. Geisinger Cancer Institute, 100 N. Academy Avenue Danville, PA 17822, USA.

9. Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.

10. The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.

11. The Ludwig Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.

12. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.

13. Department of Neurosurgery, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.

14. Department of Epidemiology, the Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street Baltimore, MD 21205, USA.

15. Department of Biostatistics, the Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street Baltimore, MD 21205, USA.

16. Department of Radiology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD, 21205, USA.

17. Department of Pathology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.

Abstract

A real-time trial of a cancer blood test Cancers diagnosed early are often more responsive to treatment. Blood tests that detect molecular markers of cancer have successfully identified individuals already known to have the disease. Lennon et al. conducted an exploratory study that more closely reflects the way in which such blood tests would be used in the future. They evaluated the feasibility and safety of incorporating a multicancer blood test into the routine clinical care of 10,000 women with no history of cancer. Over a 12-month period, the blood test detected 26 cancers of different types. A combination of the blood test and positron emission tomography–computed tomography (PET-CT) imaging led to surgical removal of nine of these cancers. Use of the blood test did not result in a large number of futile follow-up procedures. Science , this issue p. eabb9601

Funder

National Institutes of Health

Burroughs Wellcome Fund

John Templeton Foundation

Lustgarten Foundation

Virginia and D.K. Ludwig Fund for Cancer Research

Billi and Bernie Marcus Foundation

The Sol Goldman Center for Pancreatic Cancer Research

Susan Wojcicki and Dennis Troper

The Conrad R. Hilton Foundation

The Rolfe Foundation

Publisher