Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation-Reference-Cited by-同舟云学术

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

Published:2010-09-03 Issue:5996 Volume:329 Page:1201-1205
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bungard David¹,Fuerth Benjamin J.²³,Zeng Ping-Yao¹⁴,Faubert Brandon²³,Maas Nancy L.¹,Viollet Benoit⁵⁶,Carling David⁷,Thompson Craig B.⁸,Jones Russell G.²³⁸,Berger Shelley L.¹⁹¹⁰

Affiliation:

1. Department of Cellular and Developmental Biology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA.

2. Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3G 1Y6, Canada.

3. Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada.

4. Institutes of Biomedical Sciences Epigenetics Program, Mingdao Building, Room 511, Fudan University, Mail Box 281, 138 Yixue Yuan Road, Shanghai 200032, P.R. China.

5. Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France.

6. INSERM U1016, 75014 Paris, France.

7. Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London W12 0NN, UK.

8. Abramson Cancer Center and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

9. Department of Genetics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA.

10. Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Regulation of Energy Homeostasis The mammalian AMP-activated protein kinase (AMPK) is a serine/threonine kinase complex that regulates cellular energy homeostasis. However, the mechanisms by which AMPK mediates transcriptional responses to metabolic perturbations has been unclear. Bungard et al. (p. 1201 ; published online 17 August; see the Perspective by

Hardie

) have found that AMPK activated transcription directly on chromatin, combined with phosphorylation of histone H2B at Serine-36. Both signals colocalized at genes regulated in the pathway, and both the enzyme and phosphorylation were required for the direct transcription of stress-responsive genes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference19 articles.

1. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

2. AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint

3. New roles for the LKB1→AMPK pathway

4. 5′-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments

5. LKB1 Is Recruited to the p21/WAF1 Promoter by p53 to Mediate Transcriptional Activation

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