Affiliation:
1. Institut Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France.
2. CNRS UMR 144, 26 rue d’Ulm, 75248 Paris Cedex 05, France.
Abstract
ESCRT Your Wound Away
The ESCRT (endosomal sorting complex required for transport) protein complex plays a role in budding into multivesicular bodies, in cytokinesis, and in HIV budding. Now,
Jimenez
et al.
(p.
10.1126/science.1247136
, published online 30 January) propose a role for ESCRT proteins in wound repair at the plasma membrane. In vivo imaging, modeling, and electron microscopy were used to reveal how the ESCRTs participate in a rapid energy-independent, calcium-dependent, membrane-shedding process at the plasma membrane that reseals small wounds caused by toxins or laser treatment.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
510 articles.
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