Principles for designing proteins with cavities formed by curved β sheets-Reference-Cited by-同舟云学术

Principles for designing proteins with cavities formed by curved β sheets

Published:2017-01-13 Issue:6321 Volume:355 Page:201-206
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Marcos Enrique¹²³,Basanta Benjamin¹²⁴,Chidyausiku Tamuka M.¹²⁴,Tang Yuefeng⁵⁶,Oberdorfer Gustav¹²⁷,Liu Gaohua⁵⁶,Swapna G. V. T.⁵⁶,Guan Rongjin⁵⁶,Silva Daniel-Adriano¹²,Dou Jiayi²⁴⁸,Pereira Jose Henrique⁹¹⁰,Xiao Rong⁵⁶,Sankaran Banumathi¹⁰,Zwart Peter H.¹⁰,Montelione Gaetano T.⁵⁶¹¹,Baker David¹²¹²

Affiliation:

1. Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

2. Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.

3. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain.

4. Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA 98195, USA.

5. Center for Advanced Biotechnology and Medicine and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

6. Northeast Structural Genomics Consortium, Piscataway, NJ 08854, USA.

7. Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50/3, 8010-Graz, Austria.

8. Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.

9. Berkeley Center for Structural Biology, Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA.

10. Joint BioEnergy Institute, Emeryville, CA 94608, USA.

11. Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 USA.

12. Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

Abstract

Designing proteins with cavities In de novo protein design, creating custom-tailored binding sites is a particular challenge because these sites often involve nonideal backbone structures. For example, curved b sheets are a common ligand binding motif. Marcos et al. investigated the principles that drive β-sheet curvature by studying the geometry of β sheets in natural proteins and folding simulations. In a step toward custom design of enzyme catalysts, they used these principles to control β-sheet geometry and design proteins with differently shaped cavities. Science , this issue p. 201

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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