Cross-Species Interactions Between Malaria Parasites in Humans

Author:

Bruce Marian C.1,Donnelly Christl A.1,Alpers Michael P.2,Galinski Mary R.3,Barnwell John W.4,Walliker David5,Day Karen P.1

Affiliation:

1. Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, OX1 3FY, UK.

2. Papua New Guinea Institute of Medical Research, Post Office Box 378, Madang, Papua New Guinea.

3. Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Emory Vaccine Center at Yerkes, Atlanta, GA 30329, USA.

4. Biology and Diagnostic Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA.

5. Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, EH9 3JN, UK.

Abstract

The dynamics of multiple Plasmodium infections in asymptomatic children living under intense malaria transmission pressure provide evidence for a density-dependent regulation that transcends species as well as genotype. This regulation, in combination with species- and genotype-specific immune responses, results in nonindependent, sequential episodes of infection with each species.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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