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Genetic Control of Hotspots

Published:2010-02-12 Issue:5967 Volume:327 Page:791-792
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cheung Vivian G.¹,Sherman Stephanie L.²,Feingold Eleanor³

Affiliation:

1. Howard Hughes Medical Institute, Departments of Pediatrics and Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Human Genetics, Emory University, Atlanta, GA 30322, USA.

3. Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Abstract

Both chromatin and DNA sequence account for individual differences in the location and frequency of genetic recombination.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference13 articles.

1. Prdm9 Controls Activation of Mammalian Recombination Hotspots

2. PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice

3. Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic Recombination

4. Spontaneous X chromosome MI and MII nondisjunction events in Drosophila melanogaster oocytes have different recombinational histories

5. The origin of human aneuploidy: where we have been, where we are going

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