SAMTOR is an S -adenosylmethionine sensor for the mTORC1 pathway-Reference-Cited by-同舟云学术

SAMTOR is an S -adenosylmethionine sensor for the mTORC1 pathway

Published:2017-11-10 Issue:6364 Volume:358 Page:813-818
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gu Xin¹²³⁴^ORCID,Orozco Jose M.¹²³⁴^ORCID,Saxton Robert A.¹²³⁴^ORCID,Condon Kendall J.¹²³⁴^ORCID,Liu Grace Y.¹²³⁴^ORCID,Krawczyk Patrycja A.¹²³⁴^ORCID,Scaria Sonia M.¹²³⁴,Harper J. Wade⁵^ORCID,Gygi Steven P.⁵^ORCID,Sabatini David M.¹²³⁴^ORCID

Affiliation:

1. Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

2. Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

5. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

SAMTOR joins the family The amino acid methionine is widely appreciated to have interesting effects on animal physiology. Diets low in methionine increase longevity and overall health, particularly glucose homeostasis. Gu et al. describe a potential molecular link between the effects of methionine restriction and the growth controller mTOR complex 1 (mTORC1), a well-validated regulator of life span and health span in many organisms. They identify a protein that they named SAMTOR as a component of the nutrient-sensing pathway upstream of mTORC1. SAMTOR directly binds S-adenosylmethionine (SAM), a metabolite made from methionine, and is necessary for regulating mTORC1 in response to methionine. Science , this issue p. 813

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. mTOR Signaling in Growth, Metabolism, and Disease

2. Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

3. Amino acid signalling upstream of mTOR

4. The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

5. Regulation of TORC1 by Rag GTPases in nutrient response

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