A Cytidine Deaminase Edits C to U in Transfer RNAs in Archaea-Reference-Cited by-同舟云学术

A Cytidine Deaminase Edits C to U in Transfer RNAs in Archaea

Published:2009-05 Issue:5927 Volume:324 Page:657-659
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Randau Lennart¹,Stanley Bradford J.¹,Kohlway Andrew¹,Mechta Sarah¹,Xiong Yong¹,Söll Dieter¹²

Affiliation:

1. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.

2. Department of Chemistry, Yale University, New Haven, CT 06520, USA.

Abstract

Edited Information Flow RNA is generally a faithful mirror of the information encoded in DNA. However, posttranscriptional RNA editing is a widespread phenomenon that can result in a translated protein differing from its gene code. A class of deaminase enzymes related to human APOBEC (apolipoprotein B editing complex protein) edit adenosines in eukaryotes. Randau et al. (p. 657 ) have discovered an addition to this enzyme family in prokaryotes that edits cytosine to uridine at the highly conserved and structurally critical position 8 in the majority of transfer RNAs of the hyperthermophilic archaebacterium Methanopyrus kandleri .

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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