Essential Regulation of CNS Angiogenesis by the Orphan G Protein–Coupled Receptor GPR124-Reference-Cited by-同舟云学术

Essential Regulation of CNS Angiogenesis by the Orphan G Protein–Coupled Receptor GPR124

Published:2010-11-12 Issue:6006 Volume:330 Page:985-989
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kuhnert Frank¹,Mancuso Michael R.¹,Shamloo Amir²,Wang Hsiao-Ting¹,Choksi Vir³,Florek Mareike⁴,Su Hua⁵,Fruttiger Marcus⁶,Young William L.⁷,Heilshorn Sarah C.⁸,Kuo Calvin J.¹

Affiliation:

1. Department of Medicine, Hematology Division, Stanford University, Stanford, CA 94305, USA.

2. Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA.

3. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

4. Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA 94305, USA.

5. Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco (UCSF), San Francisco, CA 94110, USA.

6. UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.

7. Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, Department of Neurological Surgery, Department of Neurology, University of California, San Francisco, San Francisco, CA 94110 USA.

8. Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA.

Abstract

Plumbing in the Brain Superficial similarities of vasculature in different parts of the body may mask organ-specific developmental nuances. The vasculature of the brain uniquely has to insulate the organ from insults that the rest of the body must tolerate. Kuhnert et al. (p. 985 ) analyzed the developmental uniqueness of the brain's vasculature through study of a G protein–coupled receptor, GPR124, initially identified by its actions in the vasculature of colon cancer. GPR124 is also involved in normal development of the brain's vasculature. Mice expressing low levels of GPR124 did not develop adequate vasculature in the brain and died from hemorrhages. Mice with too much GPR124 developed a tangled, thin-walled, excessive vasculature in the brain. Although the overexpressing mice survived, they were prone to neurological symptoms such as ataxia. GPR124 seems to control the normal development of the endothelial cells, particularly in the forebrain and ventral neural tube.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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