Affiliation:
1. Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, CA 92037, USA.
Abstract
The interactive regulation between clock genes is central for oscillator function. Here, we show interactions between the
Arabidopsis
clock genes
LATE ELONGATED HYPOCOTYL
(
LHY
),
CIRCADIAN CLOCK ASSOCIATED 1
(
CCA1
), and
TIMING OF CAB EXPRESSION 1
(
TOC1
). The MYB transcription factors LHY and CCA1 negatively regulate
TOC1
expression. We show that both proteins bind to a region in the
TOC1
promoter that is critical for its clock regulation. Conversely, TOC1 appears to participate in the positive regulation of
LHY
and
CCA1
expression. Our results indicate that these interactions form a loop critical for clock function in
Arabidopsis
.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
956 articles.
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