Extensive DNA Inversions in the B. fragilis Genome Control Variable Gene Expression-Reference-Cited by-同舟云学术

Extensive DNA Inversions in the B. fragilis Genome Control Variable Gene Expression

Published:2005-03-04 Issue:5714 Volume:307 Page:1463-1465
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cerdeño-Tárraga Ana M.¹²³⁴⁵,Patrick Sheila¹²³⁴⁵,Crossman Lisa C.¹²³⁴⁵,Blakely Garry¹²³⁴⁵,Abratt Val¹²³⁴⁵,Lennard Nicola¹²³⁴⁵,Poxton Ian¹²³⁴⁵,Duerden Brian¹²³⁴⁵,Harris Barbara¹²³⁴⁵,Quail Mike A.¹²³⁴⁵,Barron Andrew¹²³⁴⁵,Clark Louise¹²³⁴⁵,Corton Craig¹²³⁴⁵,Doggett Jonathan¹²³⁴⁵,Holden Matthew T. G.¹²³⁴⁵,Larke Natasha¹²³⁴⁵,Line Alexandra¹²³⁴⁵,Lord Angela¹²³⁴⁵,Norbertczak Halina¹²³⁴⁵,Ormond Doug¹²³⁴⁵,Price Claire¹²³⁴⁵,Rabbinowitsch Ester¹²³⁴⁵,Woodward John¹²³⁴⁵,Barrell Bart¹²³⁴⁵,Parkhill Julian¹²³⁴⁵

Affiliation:

1. Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

2. Department of Microbiology and Immunobiology, School of Medicine, Queen's University of Belfast, Grosvenor Road, Belfast, BT12 6BN, UK.

3. Institute of Cell and Molecular Biology, University of Edinburgh, Darwin Building, Kings Buildings, Edinburgh EH9 3JR, UK.

4. Department of Molecular and Cell Biology, University of Cape Town, Private Bag Rondebosch 7701, South Africa.

5. Division of Medical Microbiology, University of Edinburgh Medical School, Teviot Place, Edinburgh, EH8 9AG, UK.

Abstract

The obligately anaerobic bacterium Bacteroides fragilis , an opportunistic pathogen and inhabitant of the normal human colonic microbiota, exhibits considerable within-strain phase and antigenic variation of surface components. The complete genome sequence has revealed an unusual breadth (in number and in effect) of DNA inversion events that potentially control expression of many different components, including surface and secreted components, regulatory molecules, and restriction-modification proteins. Invertible promoters of two different types (12 group 1 and 11 group 2) were identified. One group has inversion crossover ( fix ) sites similar to the hix sites of Salmonella typhimurium . There are also four independent intergenic shufflons that potentially alter the expression and function of varied genes. The composition of the 10 different polysaccharide biosynthesis gene clusters identified (7 with associated invertible promoters) suggests a mechanism of synthesis similar to the O-antigen capsules of Escherichia coli .

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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