Affiliation:
1. Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Abstract
Magnesium for
Salmonella
growth
In mammals, macrophages are a first line of defense against pathogenic bacteria like
Salmonella.
These immune cells possess a metal-ion transporter called SLC11A1 or NRAMP1, which is known to be involved in infection resistance. Cunrath and Bumann studied mice that only differ in one allele of the
SLC11A1
gene, which leaves mice either susceptible or resistant to infection. Proteomic analyses showed that bacteria isolated from mice with functional
SLC11A1
alleles experienced metal starvation, particularly of magnesium. The resulting impairment of bacterial growth seems to be the primary mode of action of SLC11A1 against invading pathogens.
Science
, this issue p.
995
Funder
Swiss National Science Foundation
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
101 articles.
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