Antibody landscapes after influenza virus infection or vaccination-Reference-Cited by-同舟云学术

Antibody landscapes after influenza virus infection or vaccination

Published:2014-11-21 Issue:6212 Volume:346 Page:996-1000
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fonville J. M.¹²³,Wilks S. H.¹²,James S. L.¹²,Fox A.⁴,Ventresca M.¹,Aban M.⁵,Xue L.⁵,Jones T. C.¹²,Le N. M. H. ⁴,Pham Q. T. ⁶,Tran N. D. ⁶,Wong Y.⁷,Mosterin A.¹²,Katzelnick L. C.¹²,Labonte D.⁸,Le T. T. ⁶,van der Net G.³,Skepner E.¹²,Russell C. A.²⁹,Kaplan T. D.¹⁰,Rimmelzwaan G. F.³,Masurel N.³,de Jong J. C.³,Palache A.¹¹,Beyer W. E. P.³,Le Q. M. ⁶,Nguyen T. H. ⁶,Wertheim H. F. L.⁴¹²,Hurt A. C.⁵¹³,Osterhaus A. D. M. E.³,Barr I. G.⁵,Fouchier R. A. M.³,Horby P. W.⁴¹²,Smith D. J.¹²³

Affiliation:

1. Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.

2. World Health Organization (WHO) Collaborating Center for Modeling, Evolution, and Control of Emerging Infectious Diseases, Cambridge CB2 3EJ, UK.

3. Department of Viroscience, Erasmus Medical Center, Rotterdam 3015 CE, Netherlands.

4. Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Vietnam.

5. WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity, Melbourne VIC 3000, Australia.

6. National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.

7. Oxford University Museum of Natural History, Oxford OX1 3PW, UK.

8. Insect Biomechanics Group, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.

9. Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.

10. bobblewire.com, Saint Louis, MO 63112, USA.

11. Abbott Laboratories, Weesp 1380 DA, Netherlands.

12. Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, University of Oxford, Oxford OX3 7BN, UK.

13. Melbourne School of Population and Global Health, University of Melbourne, Parkville VIC 3010, Australia.

Abstract

We introduce the antibody landscape, a method for the quantitative analysis of antibody-mediated immunity to antigenically variable pathogens, achieved by accounting for antigenic variation among pathogen strains. We generated antibody landscapes to study immune profiles covering 43 years of influenza A/H3N2 virus evolution for 69 individuals monitored for infection over 6 years and for 225 individuals pre- and postvaccination. Upon infection and vaccination, titers increased broadly, including previously encountered viruses far beyond the extent of cross-reactivity observed after a primary infection. We explored implications for vaccination and found that the use of an antigenically advanced virus had the dual benefit of inducing antibodies against both advanced and previous antigenic clusters. These results indicate that preemptive vaccine updates may improve influenza vaccine efficacy in previously exposed individuals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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