The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation-Reference-Cited by-同舟云学术

The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation

Published:2016-02-26 Issue:6276 Volume:351 Page:943-949
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Robert T.¹,Nore A.¹,Brun C.¹,Maffre C.¹,Crimi B.¹,Guichard V.²,Bourbon H.-M.³,de Massy B.¹

Affiliation:

1. Institute of Human Genetics, UPR 1142 CNRS, University of Montpellier, 141 Rue de la Cardonille, 34396 Montpellier cedex 05, France.

2. Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, 22 rue Mechain, 75014 Paris, France.

3. Centre de Biologie du Développement, Université Fédérale de Toulouse, Paul Sabatier Campus, 118 Route de Narbonne, 31062 Toulouse, France.

Abstract

A partner protein for meiotic snip Eukaryotes generate germ cells through meiotic recombination. This process initiates through breaks in genomic DNA catalyzed by the SPO11 protein. Vrielynck et al. and Robert et al. discover that SPO11, like topoisomerase VI enzymes, interacts with a partner protein (see the Perspective by Bouuaert and Keeney). This partner is required for proper meiotic recombination and is found in a wide range of eukaryotes, suggesting that it is a universal feature of the essential recombination step. Science , this issue p. 939 , 943 ; see also p. 916

Funder

CNRS

European Research Council

European Community's Seventh Framework Programme

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference32 articles.

1. Initiation of Meiotic Recombination: How and Where? Conservation and Specificities Among Eukaryotes

2. An atypical topoisomerase II from archaea with implications for meiotic recombination

3. Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein Family