Organogenic Role of B Lymphocytes in Mucosal Immunity-Reference-Cited by-同舟云学术

Organogenic Role of B Lymphocytes in Mucosal Immunity

Published:1999-12-03 Issue:5446 Volume:286 Page:1965-1968
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Golovkina Tatyana V.¹,Shlomchik Mark²³,Hannum Lynn²,Chervonsky Alexander¹

Affiliation:

1. Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

2. Section of Immunobiology,

3. Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract

Follicle-associated epithelium (FAE) in the intestinal Peyer's patches contains M cells that deliver pathogens to organized lymphoid tissue. Development of Peyer's patches, FAE, and M cells was found to be impaired in mice that had no B cells. Transgenic expression of membrane-bound immunoglobulin M restored B cells and FAE development. The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference63 articles.

1. Pinocytosis by epithelium associated with lymphoid follicles in the bursa of fabricius, appendix, and Peyer's patches. An electron microscopic study

2. Sequential Uptake of Horseradish Peroxidase by Lymphoid Follicle Epithelium of Peyer's Patches in the Normal Unobstructed Mouse Intestine: An Ultrastructural Study

3. The composition and function of M cell apical membranes: Implications for microbial pathogenesis

4. M cells as ports of entry for enteroinvasive pathogens: Mechanisms of interaction, consequences for the disease process

5. The M Cell as a Portal of Entry to the Lung for the Bacterial Pathogen Mycobacterium tuberculosis

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