Male Homosexuality: Absence of Linkage to Microsatellite Markers at Xq28-Reference-Cited by-同舟云学术

Male Homosexuality: Absence of Linkage to Microsatellite Markers at Xq28

Published:1999-04-23 Issue:5414 Volume:284 Page:665-667
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rice George¹,Anderson Carol¹,Risch Neil²,Ebers George¹

Affiliation:

1. Department of Clinical Neurological Sciences, University of Western Ontario, 339 Windermere Road, London, Ontario, Canada, N6A 5A5.

2. Department of Genetics, Stanford Medical School, Palo Alto, CA 94305–5120, USA.

Abstract

Several lines of evidence have implicated genetic factors in homosexuality. The most compelling observation has been the report of genetic linkage of male homosexuality to microsatellite markers on the X chromosome. This observation warranted further study and confirmation. Sharing of alleles at position Xq28 was studied in 52 gay male sibling pairs from Canadian families. Four markers at Xq28 were analyzed (DXS1113, BGN, Factor 8, and DXS1108). Allele and haplotype sharing for these markers was not increased over expectation. These results do not support an X-linked gene underlying male homosexuality.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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