Subnanoscale hydrophobic modulation of salt bridges in aqueous media-Reference-Cited by-同舟云学术

Subnanoscale hydrophobic modulation of salt bridges in aqueous media

Published:2015-05 Issue:6234 Volume:348 Page:555-559
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chen Shuo¹,Itoh Yoshimitsu¹,Masuda Takuya²,Shimizu Seishi³,Zhao Jun⁴,Ma Jing⁴,Nakamura Shugo⁵,Okuro Kou¹,Noguchi Hidenori²⁶⁷,Uosaki Kohei²⁶⁷,Aida Takuzo¹⁸

Affiliation:

1. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

2. Global Research Center for Environment and Energy based on Nanomaterials Science (GREEN), National Institute for Materials Science (NIMS), Tsukuba 305-0044, Japan.

3. York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, UK.

4. Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China.

5. Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

6. International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Tsukuba 305-0044, Japan.

7. Graduate School of Chemical Science and Engineering, Hokkaido University, Sapporo 060-0810, Japan.

8. RIKEN Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

Abstract

Ions' response to hydrophobic surfaces The strength of interactions between ions depends on their solvation environment. Schellman postulated in the 1950s that when aqueous solvated ions approached a hydrophobic surface (such as a parts of a protein surface), interactions between ions would be enhanced. Chen et al. experimentally tested this theory by studying the dissociation of organic ions bonded by salt bridges after the addition of acid. The ion pairs were held by tethers at different distances from hydrophobic surfaces. The salt bridge was stronger when it was closer to the hydrophobic surface. Science , this issue p. 555

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference46 articles.

1. Understanding Noncovalent Interactions: Ligand Binding Energy and Catalytic Efficiency from Ligand-Induced Reductions in Motion within Receptors and Enzymes

2. Surfaces Affect Ion Pairing

3. The Protein-Folding Problem, 50 Years On