Histocompatible Embryonic Stem Cells by Parthenogenesis-Reference-Cited by-同舟云学术

Histocompatible Embryonic Stem Cells by Parthenogenesis

Published:2007-01-26 Issue:5811 Volume:315 Page:482-486
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kim Kitai¹²³⁴⁵,Lerou Paul¹²³⁴⁵,Yabuuchi Akiko¹²³⁴⁵,Lengerke Claudia¹²³⁴⁵,Ng Kitwa¹²³⁴⁵,West Jason¹²³⁴⁵,Kirby Andrew¹²³⁴⁵,Daly Mark J.¹²³⁴⁵,Daley George Q.¹²³⁴⁵

Affiliation:

1. Division of Pediatric Hematology/Oncology, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA.

2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

3. Division of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA.

4. Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

5. Division of Newborn Medicine, Brigham and Women's Hospital and Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Genetically matched pluripotent embryonic stem (ES) cells generated via nuclear transfer or parthenogenesis (pES cells) are a potential source of histocompatible cells and tissues for transplantation. After parthenogenetic activation of murine oocytes and interruption of meiosis I or II, we isolated and genotyped pES cells and characterized those that carried the full complement of major histocompatibility complex (MHC) antigens of the oocyte donor. Differentiated tissues from these pES cells engrafted in immunocompetent MHC-matched mouse recipients, demonstrating that selected pES cells can serve as a source of histocompatible tissues for transplantation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

1. A functional analysis of imprinting in parthenogenetic embryonic stem cells

2. Parthenogenetic Stem Cells in Nonhuman Primates

3. Multilineage Potential of Homozygous Stem Cells Derived from Metaphase II Oocytes

4. A human parthenogenetic chimaera

5. Correction of a Genetic Defect by Nuclear Transplantation and Combined Cell and Gene Therapy

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