Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N-Reference-Cited by-同舟云学术

Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N

Published:2018-01-19 Issue:6373 Volume:359 Page:339-343
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chittori Sagar¹^ORCID,Hong Jingjun²^ORCID,Saunders Hayden²^ORCID,Feng Hanqiao²^ORCID,Ghirlando Rodolfo³^ORCID,Kelly Alexander E.²^ORCID,Bai Yawen²^ORCID,Subramaniam Sriram¹^ORCID

Affiliation:

1. Laboratory of Cell Biology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

2. Laboratory of Biochemistry and Molecular Biology, CCR, NCI, NIH, Bethesda, MD 20892, USA.

3. Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD 20892, USA.

Abstract

Recognizing centromere by kinetochore The kinetochore proteins CENP-N and CENP-C recognize the histone H3 variant CENP-A in the centromeric nucleosome. This ensures proper kinetochore assembly and accurate segregation of chromosomes. Chittori et al. describe the cryo-electron microscopy structure of the human CENP-A nucleosome-CENP-N complex. The interaction of CENP-N with CENP-A and the nucleosomal DNA together ensure specific and stable centromeric nucleosome recognition. Mutational analyses using both human and Xenopus CENP-A and CENP-N proteins suggest that the proteins have coevolved to preserve the interacting surfaces. Science , this issue p. 339

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference55 articles.

1. On the road to cancer: aneuploidy and the mitotic checkpoint

2. The molecular basis for centromere identity and function

3. Centromeres: unique chromatin structures that drive chromosome segregation

4. Dual recognition of CENP-A nucleosomes is required for centromere assembly

5. A Conserved Mechanism for Centromeric Nucleosome Recognition by Centromere Protein CENP-C

Cited by 96 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Vertebrate centromere architecture: from chromatin threads to functional structures;Chromosoma;2024-06-10

2. Integrated bioinformatics combined with machine learning to analyze shared biomarkers and pathways in psoriasis and cervical squamous cell carcinoma;Frontiers in Immunology;2024-05-28

3. Plant Artificial Chromosomes: Construction and Transformation;ACS Synthetic Biology;2024-01-01

4. Targeting CENPN to inhibit breast cancer progression: insights into cell growth and aerobic glycolysis modulation;European Journal of Gynaecological Oncology;2024

5. CENP-A and CENP-B collaborate to create an open centromeric chromatin state;Nature Communications;2023-12-12