Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth-Reference-Cited by-同舟云学术

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

Published:2021-01-08 Issue:6525 Volume:371 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Roark Ryan S.¹^ORCID,Li Hui¹^ORCID,Williams Wilton B.²³^ORCID,Chug Hema⁴^ORCID,Mason Rosemarie D.⁵^ORCID,Gorman Jason⁵^ORCID,Wang Shuyi¹^ORCID,Lee Fang-Hua¹^ORCID,Rando Juliette¹^ORCID,Bonsignori Mattia²³^ORCID,Hwang Kwan-Ki²^ORCID,Saunders Kevin O.²⁶^ORCID,Wiehe Kevin²³^ORCID,Moody M. Anthony²⁷^ORCID,Hraber Peter T.⁸^ORCID,Wagh Kshitij⁸^ORCID,Giorgi Elena E.⁸,Russell Ronnie M.¹^ORCID,Bibollet-Ruche Frederic¹,Liu Weimin¹,Connell Jesse¹^ORCID,Smith Andrew G.¹,DeVoto Julia¹,Murphy Alexander I.¹^ORCID,Smith Jessica¹,Ding Wenge¹,Zhao Chengyan¹,Chohan Neha¹^ORCID,Okumura Maho¹,Rosario Christina¹^ORCID,Ding Yu¹^ORCID,Lindemuth Emily¹^ORCID,Bauer Anya M.¹,Bar Katharine J.¹^ORCID,Ambrozak David⁵,Chao Cara W.⁵,Chuang Gwo-Yu⁵,Geng Hui⁵,Lin Bob C.⁵,Louder Mark K.⁵^ORCID,Nguyen Richard⁵^ORCID,Zhang Baoshan⁵,Lewis Mark G.⁹^ORCID,Raymond Donald D.⁴^ORCID,Doria-Rose Nicole A.⁵^ORCID,Schramm Chaim A.⁵,Douek Daniel C.⁵,Roederer Mario⁵^ORCID,Kepler Thomas B.¹⁰¹¹^ORCID,Kelsoe Garnett²⁶^ORCID,Mascola John R.⁵^ORCID,Kwong Peter D.⁵^ORCID,Korber Bette T.⁸^ORCID,Harrison Stephen C.⁴¹²^ORCID,Haynes Barton F.²³^ORCID,Hahn Beatrice H.¹^ORCID,Shaw George M.¹^ORCID

Affiliation:

1. Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

3. Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

4. Laboratory of Molecular Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

5. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

6. Departments of Immunology and Surgery, Duke University School of Medicine, Durham, NC 27710, USA.

7. Departments of Pediatrics and Immunology, Duke University School of Medicine, Durham, NC 27710, USA.

8. Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

9. Bioqual, Inc., Rockville, MD 20850, USA.

10. Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

11. Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA.

12. Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Convergent HIV evolution across species Human immunodeficiency virus (HIV) has a highly diverse envelope protein that it uses to target human cells, and the complexity of the viral envelope has stymied vaccine development. Roark et al. report that the immediate and short-term evolutionary potential of the HIV envelope is constrained because of a number of essential functions, including antibody escape. Consequently, when introduced into humans as HIV or into rhesus macaque monkeys as chimeric simian-human immunodeficiency virus, homologous envelope glycoproteins appear to exhibit conserved patterns of sequence evolution, in some cases eliciting broadly neutralizing antibodies in both hosts. Conserved patterns of envelope variation and homologous B cell responses in humans and monkeys represent examples of convergent evolution that may serve to guide HIV vaccine development. Science , this issue p. eabd2638

Funder

Howard Hughes Medical Institute

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

Simons Foundation

Penn Center for AIDS Research

Intramural Research Program of the Vaccine Research Center

NIH Training Grant in HIV Pathogenesis

The New York State Office of Science, Technology and Academic Research

Center for HIV/AIDS Vaccine Immunology-Immunogen Discovery

Consortium for HIV/AIDS Vaccine Development

Bill and Melinda Gates Foundation