Evolutionary and Biomedical Insights from the Rhesus Macaque Genome
Author:
Gibbs Richard A.12345, Rogers Jeffrey12345, Katze Michael G.12345, Bumgarner Roger12345, Weinstock George M.12345, Mardis Elaine R.12345, Remington Karin A.12345, Strausberg Robert L.12345, Venter J. Craig12345, Wilson Richard K.12345, Batzer Mark A.12345, Bustamante Carlos D.12345, Eichler Evan E.12345, Hahn Matthew W.12345, Hardison Ross C.12345, Makova Kateryna D.12345, Miller Webb12345, Milosavljevic Aleksandar12345, Palermo Robert E.12345, Siepel Adam12345, Sikela James M.12345, Attaway Tony12345, Bell Stephanie12345, Bernard Kelly E.12345, Buhay Christian J.12345, Chandrabose Mimi N.12345, Dao Marvin12345, Davis Clay12345, Delehaunty Kimberly D.12345, Ding Yan12345, Dinh Huyen H.12345, Dugan-Rocha Shannon12345, Fulton Lucinda A.12345, Gabisi Ramatu Ayiesha12345, Garner Toni T.12345, Godfrey Jennifer12345, Hawes Alicia C.12345, Hernandez Judith12345, Hines Sandra12345, Holder Michael12345, Hume Jennifer12345, Jhangiani Shalini N.12345, Joshi Vandita12345, Khan Ziad Mohid12345, Kirkness Ewen F.12345, Cree Andrew12345, Fowler R. Gerald12345, Lee Sandra12345, Lewis Lora R.12345, Li Zhangwan12345, Liu Yih-shin12345, Moore Stephanie M.12345, Muzny Donna12345, Nazareth Lynne V.12345, Ngo Dinh Ngoc12345, Okwuonu Geoffrey O.12345, Pai Grace12345, Parker David12345, Paul Heidie A.12345, Pfannkoch Cynthia12345, Pohl Craig S.12345, Rogers Yu-Hui12345, Ruiz San Juana12345, Sabo Aniko12345, Santibanez Jireh12345, Schneider Brian W.12345, Smith Scott M.12345, Sodergren Erica12345, Svatek Amanda F.12345, Utterback Teresa R.12345, Vattathil Selina12345, Warren Wesley12345, White Courtney Sherell12345, Chinwalla Asif T.12345, Feng Yucheng12345, Halpern Aaron L.12345, Hillier LaDeana W.12345, Huang Xiaoqiu12345, Minx Pat12345, Nelson Joanne O.12345, Pepin Kymberlie H.12345, Qin Xiang12345, Sutton Granger G.12345, Venter Eli12345, Walenz Brian P.12345, Wallis John W.12345, Worley Kim C.12345, Yang Shiaw-Pyng12345, Jones Steven M.12345, Marra Marco A.12345, Rocchi Mariano12345, Schein Jacqueline E.12345, Baertsch Robert12345, Clarke Laura12345, Csürös Miklós12345, Glasscock Jarret12345, Harris R. Alan12345, Havlak Paul12345, Jackson Andrew R.12345, Jiang Huaiyang12345, Liu Yue12345, Messina David N.12345, Shen Yufeng12345, Song Henry Xing-Zhi12345, Wylie Todd12345, Zhang Lan12345, Birney Ewan12345, Han Kyudong12345, Konkel Miriam K.12345, Lee Jungnam12345, Smit Arian F. A.12345, Ullmer Brygg12345, Wang Hui12345, Xing Jinchuan12345, Burhans Richard12345, Cheng Ze12345, Karro John E.12345, Ma Jian12345, Raney Brian12345, She Xinwei12345, Cox Michael J.12345, Demuth Jeffery P.12345, Dumas Laura J.12345, Han Sang-Gook12345, Hopkins Janet12345, Karimpour-Fard Anis12345, Kim Young H.12345, Pollack Jonathan R.12345, Vinar Tomas12345, Addo-Quaye Charles12345, Degenhardt Jeremiah12345, Denby Alexandra12345, Hubisz Melissa J.12345, Indap Amit12345, Kosiol Carolin12345, Lahn Bruce T.12345, Lawson Heather A.12345, Marklein Alison12345, Nielsen Rasmus12345, Vallender Eric J.12345, Clark Andrew G.12345, Ferguson Betsy12345, Hernandez Ryan D.12345, Hirani Kashif12345, Kehrer-Sawatzki Hildegard12345, Kolb Jessica12345, Patil Shobha12345, Pu Ling-Ling12345, Ren Yanru12345, Smith David Glenn12345, Wheeler David A.12345, Schenck Ian12345, Ball Edward V.12345, Chen Rui12345, Cooper David N.12345, Giardine Belinda12345, Hsu Fan12345, Kent W. James12345, Lesk Arthur12345, Nelson David L.12345, O'Brien William E.12345, Prüfer Kay12345, Stenson Peter D.12345, Wallace James C.12345, Ke Hui12345, Liu Xiao-Ming12345, Wang Peng12345, Xiang Andy Peng12345, Yang Fan12345, Barber Galt P.12345, Haussler David12345, Karolchik Donna12345, Kern Andy D.12345, Kuhn Robert M.12345, Smith Kayla E.12345, Zwieg Ann S.12345
Affiliation:
1. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. 2. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. 3. Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA. 4. Department of Microbiology, University of Washington, Seattle, WA 98195, USA. 5. Genome Sequencing Center, Washington University, St. Louis, MO 63108, USA.
Abstract
The rhesus macaque (
Macaca mulatta
) is an abundant primate species that diverged from the ancestors of
Homo sapiens
about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin
Macaca mulatta
female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Cited by
1205 articles.
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