Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II-Reference-Cited by-同舟云学术

Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II

Published:2008-03-28 Issue:5871 Volume:319 Page:1791-1792
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Core Leighton J.¹,Lis John T.¹

Affiliation:

1. Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

Abstract

Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. Elongation by RNA polymerase II: the short and long of it

2. Clustering of RNA polymerase B molecules in the 5′ moiety of the adult β-globin gene of hen erythrocytes

3. Although a large fraction of promoter-proximal Pol II can elongate in nuclear run-on assays some Pol II may be backtracked and cannot readily elongate. Therefore the broader term of stalling which includes arrest and pause has also been used.

4. The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged

5. Regulation of transcriptional elongation by RNA polymerase II

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