Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion-Reference-Cited by-同舟云学术

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

Published:2016-02-12 Issue:6274 Volume:351 Page:711-714
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Delong Thomas¹,Wiles Timothy A.¹,Baker Rocky L.¹,Bradley Brenda¹,Barbour Gene¹,Reisdorph Richard²,Armstrong Michael²,Powell Roger L.²,Reisdorph Nichole²,Kumar Nitesh³,Elso Colleen M.³,DeNicola Megan⁴,Bottino Rita⁵,Powers Alvin C.⁶⁷,Harlan David M.⁴,Kent Sally C.⁴,Mannering Stuart I.³⁸,Haskins Kathryn¹

Affiliation:

1. Department of Immunology and Microbiology, University of Colorado School of Medicine, Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.

2. Pharmaceutical Sciences, University of Colorado School of Medicine, Aurora, CO 80045, USA.

3. Immunology and Diabetes Unit, St. Vincent’s Institute of Medical Research, 9 Princes Street, Fitzroy, Victoria 3065, Australia.

4. Department of Medicine, Diabetes Division, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA.

5. Institute of Cellular Therapeutics, Allegheny-Singer Research Institute, Allegheny Health Network, Pittsburgh, PA, USA.

6. Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA.

7. VA Tennessee Valley Healthcare System, Nashville, TN, USA.

8. University of Melbourne, Department of Medicine, St. Vincent’s Hospital, Fitzroy, Victoria 3065, Australia.

Abstract

T cells target peptide combos One of the enduring mysteries of autoimmunity is the identity of the specific proteins targeted by autoimmune T cells. Delong et al. used mass spectrometry to elucidate the peptide targets of autoimmune T cells isolated from a mouse model of type 1 diabetes. T cells targeted hybrid peptides formed by the covalent linking of a peptide derived from pro-insulin to other peptides derived from proteins found in pancreatic beta cells. T cells isolated from the pancreatic islets of two individuals with type 1 diabetes also recognized such hybrid peptides, suggesting that they may play an important role in driving disease. Science , this issue p. 711

Funder

American Diabetes Association Pathway to Stop Diabetes

American Diabetes Association

Australian National Health and Medical Research Council (NHMRC)

Career Development

Operational Infrastructure Support Program

Helmsley Charitable Trust

Juvenile Diabetes Research Foundation

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject