Chromatin state dynamics during blood formation-Reference-Cited by-同舟云学术

Chromatin state dynamics during blood formation

Published:2014-08-22 Issue:6199 Volume:345 Page:943-949
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lara-Astiaso David¹,Weiner Assaf²³,Lorenzo-Vivas Erika¹,Zaretsky Irina¹,Jaitin Diego Adhemar¹,David Eyal¹,Keren-Shaul Hadas¹,Mildner Alexander¹,Winter Deborah¹,Jung Steffen¹,Friedman Nir²³,Amit Ido¹

Affiliation:

1. Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.

2. Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

3. School of Computer Science and Engineering, The Hebrew University, Jerusalem, Israel.

Abstract

Opening and closing blood enhancers As cells develop and differentiate into different types, the shape and accessibility of their DNA can change. Lara-Astiaso et al. studied this phenomenon in blood. They developed a technique that examines a relatively small number of cells to identify the changes that affect DNA during blood development. They found that the DNA of noncoding regions, called enhancers, is set in an open position when cells are undifferentiated and able to take on a variety of roles and gradually closes as cells mature into their final forms. Science , this issue p. 943

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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5. Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

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